Michihiro Mutoh Selected Research

Adenomatous Polyposis Coli (Familial Adenomatous Polyposis)

11/2023	Progression of duodenal neoplasia to advanced adenoma in patients with familial adenomatous polyposis.
1/2023	Intensive endoscopic resection for downstaging of polyp burden in patients with familial adenomatous polyposis (J-FAPP Study III): a multicenter prospective interventional study.
1/2023	Cost-effectiveness of preventive aspirin use and intensive downstaging polypectomy in patients with familial adenomatous polyposis: A microsimulation modeling study.
1/2023	Efficacy and safety of intensive downstaging polypectomy (IDP) for multiple duodenal adenomas in patients with familial adenomatous polyposis: a prospective cohort study.
3/2022	Sodium salicylate and 5-aminosalicylic acid synergistically inhibit the growth of human colon cancer cells and mouse intestinal polyp-derived cells.
1/2022	Efficacy of Low-Dose Aspirin in Colorectal Cancer Risk Prevention is Dependent on ADH1B and ALDH2 Genotype in Japanese Familial Adenomatous Polyposis Patients.
1/2021	Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a multicentre, double-blind, randomised, two-by-two factorial design trial.
1/2019	Utility of Mesalazine in Familial Adenomatous Polyposis: Clinical Report of Reduction of Polyp Size in Patients with Ulcerative Colitis, and Safety Examination in Familial Adenomatous Polyposis Patients.
1/2019	Novel screening system revealed that intracellular cholesterol trafficking can be a good target for colon cancer prevention.
2/2016	Irsogladine maleate, a gastric mucosal protectant, suppresses intestinal polyp development in Apc-mutant mice.

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Michihiro Mutoh Research Topics

Disease

71	Neoplasms (Cancer) 12/2023 - 01/2002
50	Carcinogenesis 12/2023 - 01/2002
43	Colorectal Neoplasms (Colorectal Cancer) 02/2023 - 03/2006
25	Intestinal Polyps 03/2022 - 02/2005
24	Polyps 01/2023 - 03/2006
24	Colonic Neoplasms (Colon Cancer) 03/2022 - 01/2002
16	Adenocarcinoma 01/2022 - 05/2005
15	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 08/2007
13	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 11/2023 - 04/2008
12	Adenoma (Adenomas) 01/2023 - 12/2006
9	Inflammation (Inflammations) 12/2023 - 01/2006
8	Aberrant Crypt Foci 01/2023 - 01/2002
8	Hyperlipidemias (Hyperlipidemia) 03/2013 - 02/2005
6	Body Weight (Weight, Body) 07/2021 - 10/2006
5	Obesity 07/2021 - 08/2011
3	Carcinoma (Carcinomatosis) 10/2006 - 04/2002
2	Prostatic Neoplasms (Prostate Cancer) 12/2023 - 10/2023
2	Hypoxia (Hypoxemia) 01/2019 - 01/2018
2	Lung Neoplasms (Lung Cancer) 01/2017 - 08/2015
2	Hypertriglyceridemia 01/2016 - 04/2008
2	Hyperplasia 08/2013 - 08/2008
2	Type 2 Diabetes Mellitus (MODY) 07/2013 - 10/2007

Drug/Important Bio-Agent (IBA)

20	Messenger RNA (mRNA)IBA 04/2020 - 01/2002
17	AzoxymethaneIBA 01/2023 - 01/2002
17	fucoxanthinIBA 01/2022 - 07/2017
13	Proteins (Proteins, Gene)FDA Link 11/2023 - 04/2002
13	fucoxanthinolIBA 07/2022 - 07/2017
10	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 12/2023 - 02/2013
10	LipidsIBA 07/2017 - 02/2005
9	Triglycerides (Triacylglycerol)IBA 12/2022 - 04/2006
9	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 03/2022 - 01/2002
8	colibactinIBA 02/2023 - 01/2019
8	nitrosobis(2-oxopropyl)amine (NBOP)IBA 05/2021 - 08/2007
7	AdipokinesIBA 10/2018 - 04/2008
6	CateninsIBA 12/2023 - 07/2013
6	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2023 - 02/2005
6	LigandsIBA 01/2023 - 08/2007
6	Carotenoids (Carotene)IBA 07/2022 - 12/2019
6	CarcinogensIBA 01/2019 - 01/2002
6	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 11/2015 - 03/2002
5	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2020 - 01/2018
5	Interleukin-6 (Interleukin 6)IBA 04/2020 - 01/2012
5	ProstaglandinsIBA 03/2014 - 01/2002
4	ChloridesIBA 07/2022 - 01/2005
4	EnzymesIBA 01/2022 - 01/2012
4	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2022 - 12/2019
4	Lipoprotein Lipase (Diacylglycerol Lipase)IBA 01/2012 - 02/2005
4	PPAR gammaIBA 01/2012 - 02/2005
4	Prostaglandins EIBA 03/2007 - 01/2002
4	Prostaglandin E Receptors (Prostaglandin E Receptor)IBA 01/2006 - 01/2002
3	MutagensIBA 02/2023 - 01/2020
3	AntioxidantsIBA 01/2023 - 11/2019
3	Inosine Diphosphate (IDP)IBA 01/2023 - 01/2023
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2023 - 01/2005
3	CholesterolIBA 12/2022 - 04/2006
3	Cyclin D1IBA 03/2022 - 04/2017
3	Mesalamine (Mesalazine)FDA LinkGeneric 03/2022 - 01/2019
3	Dextrans (Dextran)FDA Link 01/2022 - 11/2020
3	Insulin (Novolin)FDA Link 07/2021 - 01/2012
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 11/2015
3	LeptinIBA 01/2016 - 08/2011
3	Urethane (Ethyl Carbamate)IBA 08/2013 - 09/2008
3	Indomethacin (Indometacin)FDA LinkGeneric 11/2012 - 10/2007
3	4- diethoxyphosphorylmethyl- N- (4- bromo- 2- cyanophenyl)benzamideIBA 01/2012 - 02/2005
3	Pioglitazone (Actos)FDA Link 01/2012 - 04/2006
3	PPAR alphaIBA 10/2007 - 02/2005
2	Prostate-Specific Antigen (Semenogelase)IBA 12/2023 - 10/2023
2	Angiotensin Receptor AntagonistsIBA 12/2023 - 01/2016
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023 - 03/2011
2	CytokinesIBA 01/2023 - 04/2017
2	Small Interfering RNA (siRNA)IBA 11/2022 - 12/2021
2	CC ChemokinesIBA 01/2022 - 12/2021
2	Peptides (Polypeptides)IBA 01/2022 - 01/2020
2	PolyketidesIBA 01/2022 - 01/2020
2	XanthophyllsIBA 01/2022 - 10/2017
2	Dietary CalciumIBA 07/2021 - 09/2013
2	SuspensionsIBA 01/2021 - 01/2019
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 01/2020 - 07/2015
2	IntegrinsIBA 12/2019 - 08/2013
2	Transcription Factors (Transcription Factor)IBA 11/2019 - 08/2017
2	LuciferasesIBA 11/2019 - 08/2017
2	NF-kappa B (NF-kB)IBA 01/2019 - 10/2003
2	IsothiocyanatesIBA 01/2019 - 01/2017
2	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 08/2017 - 05/2017
2	TCF Transcription FactorsIBA 04/2017 - 07/2015
2	NADPH Oxidases (NAD(P)H oxidase)IBA 11/2015 - 03/2015
2	sesamolIBA 03/2015 - 03/2014
2	Plasminogen Activator Inhibitor 1IBA 01/2014 - 04/2008
2	AcidsIBA 08/2013 - 05/2012
2	cyclo(arginylglycyl)IBA 08/2013 - 05/2012
2	1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA 08/2013 - 05/2012
2	Plasminogen Activators (Plasminogen Activator)IBA 06/2011 - 04/2008
2	7- chloro- 3- imino- 5- methyl- 2- azabicyclo(4.1.0)heptaneIBA 08/2008 - 03/2006
2	HeptanesIBA 08/2008 - 03/2006
2	ONO 8711IBA 03/2007 - 05/2005

Therapy/Procedure

10	Chemoprevention 12/2022 - 01/2006
6	Colectomy 11/2023 - 01/2016
5	Therapeutics 01/2023 - 01/2005
2	Pancreaticoduodenectomy 10/2016 - 03/2014
2	Intraperitoneal Injections 08/2013 - 11/2012